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The TAPPS trial standard operating procedures for talc slurry and talc poudrage - Thoracoscopy and talc poudrage compared with intercostal drainage and talc slurry infusion to manage malignant pleural effusion: the TAPPS RCT. Your browsing activity is empty. Activity recording is turned off. Turn recording back on. See more...Web
Although talc is the agent mostcommonly used at the present time, there are concerns about its safety. Silver nitrate is a possible alternative agent. The purpose of thepresent …Web
Asbestos-free talc can be ordered from chemical supply companies worldwide. Talc is inexpensive, costing approximately $0.30 for a 5-g dose compared with $86.00 for 500 mg of doxycycline and $1,140.00 for 70 units of bleomycin ().Although talc is not packaged sterilely by the manufacturer, limitation on the number of microorganisms is a part of USP …Web
The present study demonstrates that talc in a slurry is an effective agent for producing pleurodesis in the rabbit model. Talc at a dose of 400 mg/kg produced gross and …Web
Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions: A Randomized Clinical Trial | Pulmonary Medicine | JAMA | JAMA Network. Figure 1. Flow of Patients in …Web
The injection of the half-dose combination was effective in producing a pleurodesis. The mean pleurodesis score in the half-dose combination group (7.1 ± 1.4) was significantly higher than that in the half-dose talc (3.2 ± 1.6) and half-dose doxycycline groups (4.1 ± 1.6) [p = 0.009 and p = 0.01, respectively; Fig 1].The quarter-dose …Web
Silver nitrate is superior to talc slurry in producing pleurodesis in rabbits. Chest (2000) FS Vargas et al. Experimental pleurodesis in rabbits induced by silver nitrate and talc: 1-year follow-up. Chest (2001) RE Mitchem et al. ... after talc slurry pleurodesis. Following the development of malignant pleural effusion, he underwent chest ...Web
Study objective: At the present time, talc administered either as a slurry or an aerosol is popular agent for producing pleurodesis. Some investigators use iodized talc while others plain talc. The purpose of the present study was to determine if iodized talc slurry produced a better pleurodesis in animals than did plain talc.Web
ceived talc slurry or poudrage for treatment of recurrent, symptomatic pleural effusions (mostly malignant). In 12 case series (14 to 356 patients) totaling 659 patients treated with ... used for producing a pleurodesis in patients with either a spontaneous pneumothorax or a recurrent pleural effusion.Web
Talc (Mg 3 Si 4 O 10 [OH] 2) is a highly effective pleurodesis agent. A recent review of over 1,200 talc pleurodesis procedures. confirmed …Web
It is concluded that talc in a slurry is a very effective pleural sclerosant in rabbits and does not produce hemothoraces as do the tetracycline derivatives. Insufflated talc is probably the most effective agent for creating a pleurodesis both in the clinical situation and in animals. However, the insufflation of talc requires an invasive procedure such as thoracoscopy or …Web
evaluate whether talc in slurry is an effective pleural sclerosant. We used an experimental rabbit model to examine the pleural changes that occur following talc slurry pleurodesis. MATERIALS AND METHODS Six normal New Zealand white rabbits weighing 2.5 to 3.5 kg were used for this study. Talc slurry preparation Talc was dry heated and ...Web
Talc has been commonly used for treatment of MPE due to its well-known effectiveness for producing pleural symphysis. ... Use of talc slurry in animal models of sterile pleuritis was reported in 1940 as a more convenient variant of Bethune's method. 8 Chambers 9 first reported the successful use of talc slurry to treat MPE in 1958. Since …Web
Discussion. The present study demonstrates that talc in a slurry is an effective agent for producing pleurodesis in the rabbit model. Talc at a dose of 400 mg/kg produced gross and microscopic pleural fibrosis to a degree that was at least as high as that produced by the intrapleural injection of tetracycline, 35 mg/kg, or minocycline 7, 10, 20, or 40 …Web
The ideal agent for producingpleurodesis has not been identified. Although talc is the agent mostcommonly used at the present time, there are concerns…Web
Background: It has been suggested that talc and doxycycline might be acting through different pathways in creating pleurodesis. We hypothesized that combining doxycycline and talc in half the usual doses would be synergistic in inducing pleurodesis. Methods: Thirty-two rabbits were equally allocated into four groups: group 1, half-dose combination (5 …Web
Talc has been commonly used for treatment of MPE due to its well-known effectiveness for producing pleural symphysis. Thoracoscopic talc poudrage was introduced by Bethune …Web
Although talc is the agent mostcommonly used at the present time, there are concerns about its safety. Silver nitrate is a possible alternative agent. The purpose of thepresent study was to compare the effectiveness of intrapleural silvernitrate and talc slurry in producing pleurodesis in rabbits.Web
TGF- β 2 may have advantages over talc slurry in the management of recurrent pleural effusion and pneumothorax. ... (TGF-β 2) is effective in producing pleurodesis in rabbits . Conventional pleurodesing agents, including talc, act indirectly by inducing pleural injury, which results in acute inflammation and subsequent fibrosis . TGF …Web
The debate on the superiority of thoracoscopic poudrage (TTI) versus talc slurry (TS) has been ongoing for decades. A meta-analysis incorporating the most recent data is useful. The methodology appears sound. The four selected articles are well described and acknowledged in most review articles as the only randomized studies …Web
Silver nitrate is superior to talc slurry in producing pleurodesis in rabbits. Chest. 2000; 118: 808-813. Abstract; Full Text; Full Text PDF; PubMed; Scopus (40) Google Scholar; The lung damage, represented by alveolar collapse, was moderate during the first 30 days after treatment, and subsequently had a clear tendency to normalize over time. 28.Web
Talc is a highly effective pleurodesis agent when administered either via poudrage or slurry in patients with pleural effusion or pneumothorax. Success rates are similar for the two …Web
When tetracycline became unavailable, the use of talc as a pleurodesis agent increased rapidly. Indeed, it is the agent most commonly used for pleurodesis at the present time (10). Talc can be administered either as an aerosol (insufflation) or a suspension (slurry). Talc is the choice of many physicians because it is inexpensive, widely ...Web
Chemical pleurodesis has become the preferred treatment for definitive management of malignant pleural effusions. The treatment of patients with recurrent benign or undiagnosed pleural effusions, however, remains a difficult clinical problem. Tetracycline has been widely used as a sclerosing agent, but parenteral tetracycline is no longer available. Therefore, …Web
The present invention provides a high solids slurry and a method for producing the same. Specifically, the present invention provides a talc slurry having a solids content of at least about 58% and a viscosity of less than about 500 centipoise. The talc slurry of the present invention comprises talc, a salt and a base.Web
It has been used for this purpose as poudrage or as slurry. Our aim was to evaluate whether talc in slurry. Pleurodesis is routinely used for the treatment of malignant pleural effusions. Talc is probably the most efficacious pleural sclerosant agent. It has been used for this purpose as poudrage or as slurry.Web
At the present time, talc administered either as a slurry or an aerosol is a popular agent for producing pleurodesis. Some investigators use iodized talc while others use plain talc. The purpose of the present study was to determine if iodized talc slurry produced a better pleurodesis in animals than did plain talc.Web
The ideal agent for producingpleurodesis has not been identified. Although talc is the agent mostcommonly used at the present time, there are concerns…Web
Talc has been commonly used for treatment of MPE due to its well-known effectiveness for producing pleural symphysis. ... Use of talc slurry in animal models of sterile pleuritis was reported in 1940 as a more convenient variant of Bethune's method. 8 Chambers 9 first reported the successful use of talc slurry to treat MPE in 1958. Since that ...Web
A talc slurry results when talc is mixed in saline solution and then gently agitated. The volume of slurry is variable; 10 to 250 ml of normal saline solution has been used. ... Treatment of chylothorax by producing pleurodesis using iodized talc. Thorax. 1965; 20: 261-269. Crossref; PubMed; Scopus (22) Google Scholar; 1965: Poudrage 5Web
